Hong Kong researchers find shortcut to predict brain diseases" dplain paper wristbandsrug effectivenessWhat To Expect At A Music Festival Festival wristbands are made up of 100% silicone, and are very popular among teenagers. These wristbands have become a unisex fashion accessory. These can be worn by children, adults and youngsters. Taking Woodstock: Rated R for graphic nudity, some sexual content, drug use and language. 120 mins. A comedy based on the real-life story of Elliot Tiber (Demetri Martin), whose family was involved in making the Woodstock Music and Arts Festival happen. The bank is about to foreclose on the family motel and Elliot moves back home to help his parents. When he learns the permit for the festival wristbands in a neighboring town has been cancelled, he contacts the producers and tries to drum up some business for the motel. Three weeks later half a million people are on their way to his neighbor"s farm and his life will be forever changed. There will be experts sharing tips on how to create positive lifestyle changes and reduce stress. Visitors can also take part in medical testing which will be free. After reading all this, you might be assuming that Healthy Living Festival is a boring, lecture-event wristbands. But it will be lots of fun as well. You can participate in a yoga class, relax with a massage and watch top chefs preparing healthy, nutritious dishes in front of you. And yes, you can watch a belly dancing show as well. Do you still think this event could be boring? A family cookout at home, block party or picnic at the Peaks of Otter is how many families will spend Labor Day. Gathering with family and friends is always a sport wristbands great way to spend time together. There is a special "Holiday Wishes" fireworks show and our family favorite "Mickey"s Once Upon a Christmastime" parade, which are both spectacular. The only time you will be able to see these shows are during the Christmas Party and between the extremely busy and extremely expensive Christmas week. That week between Christmas and New Years is the busiest of the year for the Magic Kingdom, and often closes due to capacity not long after opening in the morning! Prices vary not only according to size, but other factors also have a bearing on the cost. For example, a lined marquee is generally more expensive than an unlined one. Traditional marquees tend to be a little more expensive than frame marquees, but this is not a rule, as prices can also vary according to the design and style of the structure. Something exotic such as a Tepee could be more difficult to find and therefore more costly than a standard marquee, all other things being equal. Now, the great news for you is performing skills, like all skills, can be developed and nurtured through the right type of practice, training and coaching. And, many of these performing skills are abilities that you already possess. Further, in terms of performing, a little bit goes a long way. You will be thrilled how a few little changes make your presentation a lot more fun for you and your audience.
HONG KONG - A research team led by the City University of Hong Kong (CityU) has developed a new platform to enhance the prediction of effectiveness of medicines treating brain diseases, the university told reporter on Monday.
The result came after five years of collaboration between CityU"s Department of Biomedical Engineering (BME) and Department of Biomedical Sciences (BMS), and Harvard Medical School, the United States, aiming to provide a platform to predict compounds that have the potential to be developed into new drugs to treat brain diseases.
The research team generated the maps from the brains of thousands of zebrafish larvae, each treated with a clinically used CNS drug. The maps showed the corresponding brain regions that reacted to those drugs.
By employing machine learning strategy, the team predicted that 30 out of those 121 new compounds had anti-seizure properties. To validate the prediction, the research team randomly chose 14 from the 30 potential anti-seizure compounds to perform behavioral tests with induced seizure zebrafishes.
The result showed that 7 out of 14 compounds were able to reduce the seizures of the zebrafish without causing any sedative effects, implying a prediction accuracy of around 50 percent.
Shi Peng, Associate Professor of CityU"s BME, said that the team used robotics, microfluidics and hydrodynamic force to trap and orient an awake zebrafish automatically in 20 seconds, which allowed the imaging for many zebrafishes to be carried out in one go.
"More importantly, our platform can immobilize the fish without anaesthesia, thus avoiding interference," he added.
With this high-speed in vivo drug screening system combined with machine learning, Shi said that a shortcut is provided to help identify compounds with significantly higher therapeutic potentials for further development, hence speed up the drug development and reduce the failure rate in the process.
The research is published in the scientific journal Nature Communications.